The main feature of Peyronie's disease is penile curvature. I tried to find "penile curvature" and failed as our master had not used word penile. Upon trying to find condition penis curvature, I came across to only "priapism without curvature of penis" which also do not reflect to penile curvature. I then searched for "genital curvature" and unable to find such entry in classic homeopathic literature. Peyronie's disease is caused by formation of "hardened scar tissue beneath the skin" and unable to find exact or similar phrase in homeopathic literature even "hardened scar tissue" or "hardened scar." Though desquamation, exfoliation, peeling of hardened pieces of skin was found and I felt medicines working for such condition may affect Peyronie's disease as well and these medicines were mainly Sepia, Graphities, and Siliciea. I then tried searching with related words for hardened i.e. tough and found an entry "tissue degeneration from tough hemorrhagic infiltration" and felt may useful for Peyronie's disease and medicine for such entry was Anthracinum. Searching for "hard penis" yield with butternut shaped hard growth plate on the dorsum of penis and its medicine was Sabina. Also yielded hard swelling on penis and also hard string along upper part of penis. When searched "hard tissue" got some result and main medicines were Lap-A and Silicea. Peyronie's disease also causes pain during erection for which Canthris, Agaricus, Cann-s, Muriatic acid, and Alumina m were indicated. Peyronie's disease also causes shortening of penis and decreased flexibility for which nothing can be found in homeopathic literature. Peyronie's disease is a connective tissue disorder and found "active connective tissue with new growth" referred for Siliciea.
As in Peyronie's disease main culprit is growth of fibrous plaques in connective tissue disease, I tried to find out "growth of fibrous plaques", but unable to find such things, but found "fibrinous exudation in tissue" in Kali-Mur and "fibrinous exudation" in Iodatum, Kali-Chl, Kali-Mur, and Merc-D. Boiericke mentioned some medicines affecting positively fibrous sheath and tendon so I thought these useful too for Peyronie's disease. I found lots of medicines affecting fibrous envelope too so searching fibrous and related words was very useful. Trauma to penis is considered main cause for Peyronie's disease and found some homeopathic medicine useful for penis injury. As chronic inflammation of tunica albuginea plays a great role in development of Peyronie's disease so I considered those medicines too which are said to be effective for penis inflammation. After considering all the information given above I had given that patient Kali-Iodatum based on his symptoms and gave a marked response though not completely cured yet. One can see that case by searching "How to treat peyronie's in homeopathy" on google.